科研項目
科技部國家重點研發計劃項目,可誘導韌帶再生的高強度植入物系統的研發(2018YFC1106200),參與,2018.09-2021.06,總經費7246萬
科技部國家重點研發計劃課題,生物醫用防粘連疝氣補片開發及應用(2016YFB0303300-03),參與,2016.01-2020.12,總經費1535萬
上海市教育委員會科研創新項目,人工血管移植仿真環境構建及細胞黏附研究(ZX201503000017),主持,2015.01-2017.12,8萬
國家自然科學基金青年基金,抗血栓及促内皮化混構小口徑人造血管研究(51003014),主持,2011.1-2013.12,19萬
中國博士後科學基金面上項目,雙功能小口徑人造血管研究(20100480570),主持,2009.9-2011.8,3萬
主持其他項目:
紡織基鎢纖維人工胸壁材料研究、面向空降兵高空着陸用非對稱結構護踝、水凝膠小口徑人工血管材料研究、高順應性二元小口徑人工血管研究、紡織基人工血管材料表面細胞黏附研究、仿真環境下絲滌小口徑人造血管與血管内皮細胞相互作用機制研究、具抗凝血及促内皮化雙功能小徑人造血管的制備等
主持企業委托科技項目:食管支架、面向空降兵的踝護具技術要求及測試、複雜結構網塞剛度評價研究、一次性使用抗菌衛生材料等
參與企業委托科技項目:一體式編織血管覆膜支架、取石網籃等
參與其他項目:誘導軟組織再生醫用紡織材料
代表性英文論文
1. Chenglong Yu, Guoping Guan*, Stefanie Glas, Lu Wang, Zhutong Li, Lih-Sheng Turng*. A biomimetic basement membrane consisted of hybrid aligned nanofibers and microfibers with immobilized collagen IV and laminin for rapid endothelialization, Bio-Design and Manufacturing, 2021(1), 1-19
2. Chenglong Yu, Meiyi Xing, Lu Wang, Guoping Guan*. Effects of aligned electrospun fibers with different diameters on hemocompatibility, cell behaviors and inflammation in vitro. Biomedical Materials. 2020, 15(3), DOI: 10.1088/1748-605X/ab673c 3.174, II區
3. WU, Jiawei; LIU, Mingjie; wang, Lu; Guan, Guoping*, Influence of Silk Fibroin/Sodium Alginate Coatings on Mineralization of Silk Fibroin Fiber Artificial Ligament Prototypes, Textile Research Journal. 2020, DOI: 10.1177/0040517519898156
4. Yufen WU, Chenglong YU, Meiyi XING, Lu WANG, Guoping GUAN*, Surface modification of polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels with polydopamine and REDV for improved applicability, Journal of biomedical materials research: Part B. 2020, DOI: 10.1002/jbm.b.34371
5. Xing, meiyi; Yu, Chenglong; Wu, Yufen; wang, Lu; Guan, Guoping*, Preparation and Characterization of PVA/PAAm Hydrogel Vascular Graft Reinforced with Braided Fiber Stent, Textile Research Journal, 2019, DOI: 10.1177/0040517519896753
6. Wen Xue, Seyedmehdi Hossaini Nasr, Guoping Guan*, Liheng Gao, Fan Zhao, Jing Gao, Fujun Wang, Chunqi Qian*, Lu Wang*. An Efficient Surface Modification Strategy Improving Endothelialization with Polydopamine Nanoparticles and REDV Peptides for Stent-Grafts. ACS Applied Bio Materials 2019, 2 (9) , 3820-3827. DOI: 10.1021/acsabm.9b00421.
7. Chonglong YU, Meiyi Xing, Shibo Sun, Guoping Guan*, Lu Wang*. In vitro vascular endothelial cells behaviors on a biomimetic vascular basement membrane. Colloids and Surfaces B: Biointerfaces, 2019, 182 :110381. DOI: 10.1016/j.colsurfb.2019.110381
8. Guoping Guan, Yufen Wu, Chenglong Yu, Xingyou Hu, Meiyi Xing, Wei Wang, Yexiang Wang, Hongjun Wang, Lu Wang*, Hydrogel small diameter vascular graft reinforced with a braided fiber strut for improved mechanical properties, Polymers, 2019, 11, 810; DOI:10.3390/polym11050810
9. Xingyou Hu, Gaotian Shen, Tao Hu, Guoping Guan*, Lu Wang*, Use of an in vitro dynamic culture system to assess flow shear forces upon cell adhesion within different structures, J Chem Technol Biotechnol (2018), DOI:10.1002/jctb.5834
10. Hu X, Hu T, Guan G*, Yu S, Wu Y, Wang L*. 2018. Control of weft yarn or density improves biocompatibility of PET small diameter artificial blood vessels. J Biomed Mater Res Part B 2018:106(3):954–964
第一發明人授權發明專利
1. 一種單紗醫用多功能鼻塞及其制備方法,授權時間:2020-08-25 2. 一種非對稱結構踝護具個性化快速制備方法,授權時間:2019-09-27 3. 壓強可控的人工血管整體水滲透性測試儀及其使用方法,授權時間:2019-09-19 4. 非對稱結構踝護具個性化快速制備方法,授權時間:2019-02-26 5. 絲素蛋白纖維規模化生産的全自動脫膠裝備及其使用方法,授權時間:2018-12-04 6. 一種測試網塞抗彎剛度的環托法,授權時間:2018-12-04 7. 一種防護踝關節内翻的半剛性踝護具及其制備方法,授權時間:2018-06-22 8. 一種網塞抗壓剛度的測試方法,授權時間:2018-05-15 9. 一種脈動式人工血管整體水滲透性測試儀及其使用方法,授權時間:2017-08-01 10. 一種管道器官澆注成型裝置及其使用方法,授權時間:2016-11-30 11. 管狀纖維集合體增強管道器官澆注成型裝置及其使用方法,授權時間:2016-04-06 12. 一種三層機織小口徑人造血管及其制備方法,授權時間:2013-06-26 專著及教材 1. 關國平,第2章《醫用紡織品的生物學基礎》,王璐,Martin W KING主編,《生物醫用紡織品》,中國紡織出版社,2011.11,ISBN: 9787506478892 2. Biobased Composites for Medical and Industrial Applications (2/3). in Porous lightweight composites reinforced with fibrous structure. Springer press, 2017. ISBN 978-3-662-53802-9. Yiqi Yang, Jianyong Yu, Helan Xu, Baozhong Sun Editors. 3. 副主編,《生物醫用紡織品測試與評價》,王璐 主編,上海:402永利出版社 4. 《生物醫用紡織品設計與制備》,王璐 主編,上海:402永利出版社